Updated: Apr 1, 2020
Autophagy is a buzz word these days. For those of you that somehow have missed the 𝟺𝟷𝟷 on it; 𝘪𝘵’𝘴 𝘦𝘴𝘴𝘦𝘯𝘵𝘪𝘢𝘭𝘭𝘺 𝘵𝘩𝘦 𝘤𝘭𝘦𝘢𝘯𝘦𝘳 𝘰𝘧 𝘺𝘰𝘶𝘳 𝘣𝘰𝘥𝘺, degrading damaged and dysfunctional cells and protein structures before they cause problems in the body.
Many individuals promote it as being the 𝘴𝘢𝘷𝘪𝘯𝘨 𝘨𝘳𝘢𝘤𝘦 𝘰𝘧 𝘩𝘦𝘢𝘭𝘵𝘩 and recommend prolonged fasting to maximize its up-regulation, but that isn’t necessary.
Autophagy is always going on due to its necessity for cleaning up and the #𝟭 thing that stimulates it is a cellular energy deficit.
Regardless of any other factors, such as nutrient signaling from amino acids, or growth factor signaling from hormones like insulin — an energy deficit within the cell prevails and promotes the activation of the autophagy regulator, AMPK, which sits on a see-saw with the master regulator of growth and reproduction, mTOR.
Ideally, we want to balance our 𝗽𝗲𝗿𝗶𝗼𝗱𝘀 𝗼𝗳 𝗳𝗮𝘀𝘁𝗶𝗻𝗴 𝘄𝗶𝘁𝗵 𝗽𝗲𝗿𝗶𝗼𝗱𝘀 𝗼𝗳 𝗳𝗲𝗮𝘀𝘁𝗶𝗻𝗴, so that we get the best of both mTOR and AMPK. It’s sufficient to fast for 12-16 hours every night as we sleep, depending on your goals, and then eat within the remaining time so that you can spend some time growing and building new tissue, then cleaning up any dysfunctional proteins that come about during that growth period.
𝘗𝘳𝘰𝘭𝘰𝘯𝘨𝘦𝘥 𝘧𝘢𝘴𝘵𝘪𝘯𝘨 𝘭𝘦𝘢𝘥𝘴 𝘵𝘰 𝘦𝘹𝘤𝘦𝘴𝘴𝘪𝘷𝘦 𝘢𝘯𝘥 𝘶𝘯𝘯𝘦𝘤𝘦𝘴𝘴𝘢𝘳𝘺 𝘮𝘶𝘴𝘤𝘭𝘦 𝘭𝘰𝘴𝘴. It’s fine if you are very obese, but it’s not ideal, and it is certainly not beneficial to anyone who is already at a healthy body weight.
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