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Autophagy is a buzz word these days. For those of you that somehow have missed the ๐บ๐ท๐ท on it; ๐ช๐ตโ๐ด ๐ฆ๐ด๐ด๐ฆ๐ฏ๐ต๐ช๐ข๐ญ๐ญ๐บ ๐ต๐ฉ๐ฆ ๐ค๐ญ๐ฆ๐ข๐ฏ๐ฆ๐ณ ๐ฐ๐ง ๐บ๐ฐ๐ถ๐ณ ๐ฃ๐ฐ๐ฅ๐บ, degrading damaged and dysfunctional cells and protein structures before they cause problems in the body. โฃ
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Many individuals promote it as being the ๐ด๐ข๐ท๐ช๐ฏ๐จ ๐จ๐ณ๐ข๐ค๐ฆ ๐ฐ๐ง ๐ฉ๐ฆ๐ข๐ญ๐ต๐ฉ and recommend prolonged fasting to maximize its up-regulation, but that isnโt necessary.โฃ
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Autophagy is always going on due to its necessity for cleaning up and the #๐ญ thing that stimulates it is a cellular energy deficit. โฃ
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Regardless of any other factors, such as nutrient signaling from amino acids, or growth factor signaling from hormones like insulin โ an energy deficit within the cell prevails and promotes the activation of the autophagy regulator, AMPK, which sits on a see-saw with the master regulator of growth and reproduction, mTOR.โฃ
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Ideally, we want to balance our ๐ฝ๐ฒ๐ฟ๐ถ๐ผ๐ฑ๐ ๐ผ๐ณ ๐ณ๐ฎ๐๐๐ถ๐ป๐ด ๐๐ถ๐๐ต ๐ฝ๐ฒ๐ฟ๐ถ๐ผ๐ฑ๐ ๐ผ๐ณ ๐ณ๐ฒ๐ฎ๐๐๐ถ๐ป๐ด, so that we get the best of both mTOR and AMPK. Itโs sufficient to fast for 12-16 hours every night as we sleep, depending on your goals, and then eat within the remaining time so that you can spend some time growing and building new tissue, then cleaning up any dysfunctional proteins that come about during that growth period.โฃ
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๐๐ณ๐ฐ๐ญ๐ฐ๐ฏ๐จ๐ฆ๐ฅ ๐ง๐ข๐ด๐ต๐ช๐ฏ๐จ ๐ญ๐ฆ๐ข๐ฅ๐ด ๐ต๐ฐ ๐ฆ๐น๐ค๐ฆ๐ด๐ด๐ช๐ท๐ฆ ๐ข๐ฏ๐ฅ ๐ถ๐ฏ๐ฏ๐ฆ๐ค๐ฆ๐ด๐ด๐ข๐ณ๐บ ๐ฎ๐ถ๐ด๐ค๐ญ๐ฆ ๐ญ๐ฐ๐ด๐ด. Itโs fine if you are very obese, but itโs not ideal, and it is certainly not beneficial to anyone who is already at a healthy body weight.
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